Acta Medica Bulgarica

Постоянни адреси на тази колекция

Многопрофилно списание, излизащо само на английски език от 1973 г. и до момента. Съдържа авторски статии от водещи български медицински специалисти, отразяващи върховите постижения на българската медицина наука и практика. Публикуват се материали, отразяващи резултати от експериментални проучвания, клиника и казуистика. ***** Излиза 2 пъти годишно. ***** ISSN:0324-1750 ***** Уебсайт: http://www.medun.acad.bg/cmb_htm/AMB/index.html ***** About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica. For over 20 years, the staff of „Medicine and Physical Culture" did all the work related to the publishing of AMB regardless of the fact that the magazine kept on its appearance as organ of the Medical Academy, respectively of the Sofia Medical University. Editors-in-chief throughout the years were prof. Atanas Maleev, prof. Nikolay Belovezhdov, prof. Dimitar Djerov and prof. Vladimir Ovcharov. Gradually a greater number of scientists from all over the world as well as universities and scientific institutes demonstrated stronger interest in publishing their papers in AMB. The magazine is in demand by over 300 world medical libraries working on the exchange principle. For the last couple of years, AMB has been organ of the Sofia Medical University has been published by the Central Medical University Library - department of Medical Information. More than 30 years prof. Wenzeslav Bossnev has been responsible for the scientific edition of the magazine, while prof. Stoian Danev was later committed to the English version. The editorial staff respectfully marks out the joint efforts of all the colleagues that have of to the publishing of the magazine during the years of complex changes in social life and wishes the next generation of scientists to further develop and improve its scientific level and consolidate its position among international medical literature. ***** ISSN:0324-1750 ***** Website: http://www.medun.acad.bg/cmb_htm/AMB/index.html

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  • Документ
    Сравнение на профила на безопасност на биоподобни с техните референти // Comparison of the safety profile of biosimilars with their reference products
    (Медицински университет – София // Medical University – Sofia, 2024) Копанаров, Валентин Костадинов // Kopanarov, Valentin Kostadinov
    Цел: Настоящето изследване има за цел да проучи, сравни и анализира регулаторната рамка и обществено-достъпната информация по отношение на мониторирането на лекарствената безопасност на биоподобните ЛП спрямо техните референтни ЛП, разрешени за употреба в ЕС. Задачи: 1. Проучване на регулаторните изисквания при разрешаване за употреба на биоподобни ЛП в ЕС към 11.2022 г. 2. Преглед и анализ на лекарствените регулации по отношение на биологичните и биоподобните ЛП в ЕС, вкл. и в България. 3. Преглед и анализ на разрешените за употреба биоподобни ЛП в ЕС от 04.2006 г. до 11.2022 г. 4. Преглед и анализ на биоподобните ЛП с отказано или прекратено разрешение за употреба в ЕС от 04.2006 г. до 11.2022 г., вкл. и подлежащите мотиви. // Aim: This study aims to explore, compare, and analyze the regulatory framework and publicly available information regarding the pharmacovigilance monitoring of biosimilar MPs against their reference MPs authorized in the EU. Objectives: 1. Study of regulatory requirements for the authorization of biosimilar MPs in the EU as of 11.2022. 2. Review and analysis of drug regulations regarding biological and biosimilar MPs in the EU, including Bulgaria. 3. Review and analysis of authorized biosimilar MPs in the EU from 04.2006 to 11.2022. 4. Review and analysis of biosimilar MPs with refusal or withdrawal of marketing authorization in the EU from 04.2006 to 11.2022, including the underlying motives.
  • Документ
    Role of leptin in oxidative stress and survival of human granulosa luteinized cells in vitro
    (Централна медицинска библиотека - МУ София / Central Medical Library - MU Sofia, 2013-09) Dineva, J.; Vangelov, I.; Rangelov, I.; Stamenov, G.; Fartsova, T.
    Summary. The aim of this study was to investigate the effect of leptin on oxidative status and survival of human granulosa luteinized cells (GLCs) in vitro. The human GLCs were isolated from follicular fl uids of women undergoing IVF procedure and cultured in DMEM /HAM F12 with 10% FCS for 24 h. To study the oxidative status and survival of GLCs, after a 24-hour culture period, the cells were supplemented with 0, 1, 10, 100 ng/ml leptin in DMEM/ HAM F12 plus 1% FCS and cultured for another 24 h. The level of malondialdehyde (MDA), formed during the decomposition of lipid peroxidation products in cells, was measured by TBARS Assay Kit. Using the specifi c substrate (AcDEVD-PNA), the caspase-3 activity was measured as an indicative marker for apoptosis. Treatment with a physiological dose of leptin (10 ng/ml) decreased MDA level, while the higher dose of leptin (100 ng/ml) resulted in increased MDA level, compared to control cells (p < 0.05). Moreover, the treatment of GLCs with 100 ng/ml of leptin led to a significant increase in caspase-3 activity compared to control cells or cells treated with 10 ng/ml leptin (p < 0.05). The higher concentration of MDA was related to higher caspase-3 activity (R = 0.5789, p = 0.049). In conclusion, leptin plays an important role in oxidative metabolism and survival of human granulosa luteinized cells.
  • Документ
    A rare case of a patient with a metatypical basal cell carcinoma of the forehead treated successfully with elliptical excision
    (Централна медицинска библиотека - МУ София / Central Medical Library - MU Sofia, 2013-09) Tchernev, G.; Ananiev, J.; Cardoso, J. C.
    Summary: We present a rare case of a 72-year-old patient with an ulcerative lesion localized to the left forehead, appearing 3 months prior to clinical presentation. Biopsy revealed a metatypical basal cell carcinoma. Treatment consisted of wide local excision. There was no sign of recurrence or metastasis after a 12-month follow-up period. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) make up 95% of the most common type of cancer in the world, the non-melanoma skin cancer. BCC is known for its potential to be locally invasive, while SCC for its potential to metastasize in lymph nodes. Metatypical basal cell carcinoma (MTBC) is a rare tumor that combines clinical and histopathological features of both BCC and SCC. The gold standard for diagnosis lies in the histopathologic examination. Clinical examination alone does not suffi ce.
  • Документ
    Anterograde facial-submental artery island fl ap for palate repair after carcinoma ablation – a case report
    (Централна медицинска библиотека - МУ София / Central Medical Library - MU Sofia, 2013-09) Yordanov, Y.; Shef, A.; Lasso, J. M.
    Summary. The submental island fl ap is a reliable alternative in the armamentarium of the plastic surgery for reconstruction of various head and neck defects including those affecting the oral mucosa and the palate. Since it was fi rst described, it has been affirmed as a safe, rapid and easy reconstruction method with minimal to missing donor site morbidity.We present a clinical case of complete reconstruction of soft palate using an anterograde pattern submental fl ap. We believe this flap to be safer than the reverse-fl ow one that has been typically used for defects located in this region. The surgical technique is described.
  • Документ
    Sternal wound reconstruction with porcine acellular dermal matrix (strattice) for poststernotomy mediastinitis
    (Централна медицинска библиотека - МУ София / Central Medical Library - MU Sofia, 2013-09) Y. Yordanov; A. Shef; V. Vaseva; J. M. Lasso
    Summary. Sternal reconstruction could be a complex and challenging procedure. Common indications are defects after heart surgery, infections, tumour ablation, radiation necrosis, congenital deformities and trauma. Aloplastic materials are often used for sternal stabilization and regional fl aps are applied to provide well vascularized soft tissue coverage. Although numerous materials are available, acellular dermal matrice have some advantage that could be of benefi t in the repair of the anterior mediastinum and chest wall. We present a case of a 72-year-old male patient whit mediastinitis and sternal dehiscence after triple-vessel coronary artery bypass grafting and failure of the initial chest wall closure. After conservative treatment and VAC-therapy, titanium plates were used to restore the sternal continuity. Porcine acellular dermal matrix (Strattice™ Tissue Matrix) was applied for wrapping the fi xation plates and reinforcing the pectoralis muscle fl aps used for soft tissue coverage. Due to its ability to become incorporated and vascularized, to resist wound infections and to provide stability, Strattice seems to be a promising, although probably not enough effi cient alternative of the synthetic materials. To our knowledge, this is the fi rst report in the Bulgarian scientifi c literature of sternal reconstruction by using a porcine acellular dermal matrix (Strattice).
Централна медицинска библиотека, МУ София / Central Medical Library, MU Sofia