Effect of chronic alcohol consumption on apoptosis of lymphocytes: role of caspase-3 and fas ligands
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Дата
2011-10
Автори
Boyadjieva, N.
Bocheva, G.
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Издател
Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia
Резюме
Ethanol has been shown to acutely increase the apoptosis in various
cells. But the effect of ethanol on FasL-mediated apoptosis of lymphocytes is
not well established. The aim of present study is to evaluate the mitogen-induced
proliferation in vitro and apoptosis of lymphocytes obtained from the spleens of
alcohol and nonalcohol fed rats. We also determined whether caspase-3 or soluble
FasL play a role in apoptotic effect of ethanol on lymphocytes. Here, we found that
chronic alcohol administration increased both apoptosis and caspase-3 activity and
decreased the number of T lymphocytes via depressing the proliferation and activating
the apoptotic cell death in cultured splenocytes. Furthermore, we identifi ed
that caspase-3 and soluble FasL play a role in apoptosis of lymphocytes.
Описание
Address for corespondence:
N. Boyadjieva;
Department of Pharmacology and Toxicology;
Medical Faculty;
Medical University - Sofia;
2 Zdrave str.;
1431 Sofia;
tel. 02 91-72-61
Ключови думи
apoptosis, Fas, Fas ligand (FasL), alcohol, caspase-3, T cells
Цитирания
N. Boyadjieva and G. Bocheva. Effect of chronic alcohol consumption on apoptosis of lymphocytes: role of caspase-3 and fas ligands - Acta medica bulgarica , 38, 2011, No 2, 22-29.