Effect of chronic alcohol consumption on apoptosis of lymphocytes: role of caspase-3 and fas ligands
| dc.contributor.author | Boyadjieva, N. | |
| dc.contributor.author | Bocheva, G. | |
| dc.date.accessioned | 2014-02-07T10:25:56Z | |
| dc.date.available | 2014-02-07T10:25:56Z | |
| dc.date.issued | 2011-10 | |
| dc.description | Address for corespondence: N. Boyadjieva; Department of Pharmacology and Toxicology; Medical Faculty; Medical University - Sofia; 2 Zdrave str.; 1431 Sofia; tel. 02 91-72-61 | en_US |
| dc.description.abstract | Ethanol has been shown to acutely increase the apoptosis in various cells. But the effect of ethanol on FasL-mediated apoptosis of lymphocytes is not well established. The aim of present study is to evaluate the mitogen-induced proliferation in vitro and apoptosis of lymphocytes obtained from the spleens of alcohol and nonalcohol fed rats. We also determined whether caspase-3 or soluble FasL play a role in apoptotic effect of ethanol on lymphocytes. Here, we found that chronic alcohol administration increased both apoptosis and caspase-3 activity and decreased the number of T lymphocytes via depressing the proliferation and activating the apoptotic cell death in cultured splenocytes. Furthermore, we identifi ed that caspase-3 and soluble FasL play a role in apoptosis of lymphocytes. | en_US |
| dc.identifier.citation | N. Boyadjieva and G. Bocheva. Effect of chronic alcohol consumption on apoptosis of lymphocytes: role of caspase-3 and fas ligands - Acta medica bulgarica , 38, 2011, No 2, 22-29. | en_US |
| dc.identifier.issn | 0324-1750 | |
| dc.identifier.uri | http://hdl.handle.net/10861/428 | |
| dc.language.iso | en | en_US |
| dc.publisher | Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia | en_US |
| dc.subject | apoptosis, Fas, Fas ligand (FasL), alcohol, caspase-3, T cells | en_US |
| dc.title | Effect of chronic alcohol consumption on apoptosis of lymphocytes: role of caspase-3 and fas ligands | en_US |
| dc.type | Article | en_US |