Association between biochemical markers of bone turnover and markers in the estrogen receptor (ER) gene
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Дата
2010-10
Автори
Ivanova, Zh.
Toshev, А.
Tsachev, K.
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Издател
Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia
Резюме
Bone metabolism is characterized by two opposite activities: the formation of new bone by osteoblasts and the degradation of old bone by the osteoclasts.
Osteoporosis is a disease in which subtle modifi cations of bone remodeling
can result in a substantial loss of bone over a prolonged period of time. The needs
for non-invasive techniques that can be applied more widely and repeated several
times in a single patient explain the development of markers of bone turnover that
are measured in blood and urine. The prognostic value of parameters as risk indexes
for osteoporosis is not enough. This makes it possible to use genetic markers,
which together with already existing risk indexes will improve the identifi cation
of individuals with higher osteoporosis risk. The future development of genetic
studies in osteoporosis will proceed in two major directions: identifi cation of further
candidate genes, their interaction with each other and their application to defi ned
diseases of bone metabolism.
Abbreviations: (BMD) bone mineral density; (ER) estrogen receptor; (Pyr) pyridinoline;
D-Pyr) deoxypyridinoline; (Cr) creatinine
Описание
Address for correspondence:
Zhivka Ivanova;
Medical University – Sofia;
Department of Biology;
Zdrave 2 Str.;
e-mail: jivka_iva@yahoo.com ;
Mobile tel.: +359 887 760 503
Ключови думи
osteocalcin, deoxypyridinoline, estrogen receptor (ER), bone mineral density (BMD)
Цитирания
Zh. Ivanova, А. Toshev and К. Tsachev. Association between biochemical markers of bone turnover and markers in the estrogen receptor (ER) gene - Acta Medica Bulgarica, 37, 2010, № 2, 3-14.