Mesangial lipoidosis with cholesterol deposition – a new case with nephrotic syndrome and rapidly progressing renal failure
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Дата
2011-10
Автори
Robeva, R.
Todorov, T.
Dimitrova, V.
Yordanov, M.
Doychinov, D.
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ISSN на списанието
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Издател
Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia
Резюме
More than 140 years ago, fi rst Virchow associated observed lipid
abnormalities with the concomitant renal disease. Despite a large body of clinical
and laboratory evidence, the precise role of the lipids in the development of the
renal disease remains unclear. In 1988, D. Doychinov described a new autosomal
dominant hereditary disease leading to cholesterol accumulation within the glomerular
mesangium. We report the case of a young man (a member of the affected
family) with the same biopsy proven disease but with different clinical abnormalities
and course. This patient had an overt nephrotic syndrome from the onset: 5 g/24h
proteinuria, hypoproteinemia (52 g/l), hypoalbuminemia (28 g/l), hypercholesterolemia
(8.5 mmol/l), edema as well as severe hypertension (180-200/110-120 mm
Hg). Five years later he developed renal failure and after another three he was put
on hemodialysis.
Описание
Address for correspondence:
Assoc. Prof. R. Robeva, MD;
Univ. Hosp. ”St . Ivan Rilski”;
Dialysis and Clinical Pharmacology;
15, Blvd.” Acad. Ivan Geshov”;
1431 Sofia;
tel. +35928510846
Ключови думи
mesangial lipoidosis, nephrotic syndrome, renal insuffi ciency
Цитирания
R. Robeva, T. Todorov, V. Dimitrova, M. Yordanov and D. Doychinov. Mesangial lipoidosis with cholesterol deposition – a new case with nephrotic syndrome and rapidly progressing renal failure - Acta medica bulgarica , 38, 2011, No 2, 62-66.