Genetic aberrations in adult CD10 positive/cytoplasmic IgM negative B-cell acute lymphoblastic leukemia
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Дата
2013-06
Автори
Velizarova, M.
Popova, D.
Hadzhiev, E.
Dimova, I.
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Издател
Централна медицинска библиотека - МУ София / Central medical Library - MU Sofia
Резюме
In the recent years progress in the basic laboratory science has
allowed for implementation of many advanced methods in the clinical practice.
Flow cytometry is a method, which is most commonly used for clinical diagnosis of
‘de novo’ acute leukemias, and in combination with molecular-cytogenetic studies
provides more opportunities for determination of patients’ risk factors and disease
prognosis. We report on high percentage of adult CD10(+)/cyIgM(-) B-cell acute
lymphoblastic leukemia (56% of all studied B-ALL) and unusual for this group chromosome
findings - (8q24)/C-MYC, trizomy 8, t(1;19), no ploidy changes and low
t(9;22) frequency.
Описание
Address for correspondence:
Dr. Milena Velizarova;
Department of Clinical Laboratory and Clinical Immunology;
University Hospital Aleksandrovska;
1 G. Sofiyski St.;
1431 Sofia, Bulgaria;
e-mail: mvelizarova@abv.bg
Ключови думи
cytogenetics, adult acute lymphoblastic leukemia, CD10(+) acute leukemia
Цитирания
M. Velizarova, D. Popova, E. Hadzhiev and I. Dimova. Genetic aberrations in adult CD10 positive/cytoplasmic IgM negative B-cell acute lymphoblastic leukemia - Acta medica bulgarica , 40, 2013, No 1, 3-9.