Експресията на IMP-3 при невус и меланома: Още ли няма светлина в края на тунела?

thumbnail.default.placeholder
Дата
2015-12
Автори
Чокоева/Chokoeva, А./A.
Чернев/Tchernev, Г./G.
Волина/ Wollina, У./U.
Лоти/Lotti, Т./T.
Заглавие на списанието
ISSN на списанието
Заглавие на тома
Издател
Централна медицинска библиотека, МУ София / Central Medical Library, MU Sofia
Резюме
What is new in the diagnosis and treatment of melanoma and other melanocytic potentially dangerous lesions? We would like to focus the attention on the interesting and independent preliminary findings, considering the expression of IMP-3 in small groups of benign, dysplastic melanocytic lesions and melanomas, reported most recently by some authors [1], which showed the following expression pattern: IMP-3 positive expression in 4 of the 10 melanomas (40%) and in 2 of 10 dysplastic nevi (20%), while no expression was observed in the benign nevi. This observation supports the important new statement that IMP-3 could be a useful marker for the differentiation between benign and dysplastic nevi or melanoma, but it is still not a useful marker for distinguishing the dysplastic nevi from melanoma, since an expression has been observed in both of them [1]. IMP-3 is generally considered as an oncofetal protein, as a remarkable overexpression of IMP-3 has been recently reported in association with different neoplasms, including malignant melanoma, as its important prognostic value, is highlighted [2]..........
Описание
Dr Anastasiya Atanasova Chokoeva, “Onkoderma” – Policlinic for Dermatology, and Dermatologic Surgery, General Skobelev 26 blvd., 1407 Sofia, Bulgaria, e-mail: assia_chokoeva@abv.bg
Ключови думи
Меланома- диагноза; меланома-лечение; ексрпесия на IMP-3 , melanoma-diagnosis; melanoma-therapy; expression of IMP-3;
Цитирания
А. Чокоева, Г. Чернев, У. Волина и Т. Лоти. Експресията на IMP-3 при невус и меланома: Още ли няма светлина в края на тунела? - Медицински преглед, 51, 2015, № 6, 67-68.