Valproate-induced parkinsonism in epilepsy patient – a case report
| dc.contributor.author | Maximov, K. | |
| dc.contributor.author | Maximov, G. | |
| dc.date.accessioned | 2012-05-07T13:07:00Z | |
| dc.date.available | 2012-05-07T13:07:00Z | |
| dc.date.issued | 2008-06 | |
| dc.description | Address for correspondence: K. G. Maximov, MD Military Medical Academy – Sofia, Bulgaria Medical Center for Neurology and Neurosurgery „Neuromed” Bul. G. Sofiisky №1 Sofia, Bulgaria tel: 0035929225644 e-mail: neuromaxi@yahoo.com | en_US |
| dc.description.abstract | Valproate (VPA) is one of the most commonly used anti-epileptic drugs troughout the world. It is generally considered to have a good safety profil. Among the side effects due to valproate administration, parkinsonism is the rarest in frequency. This side effect is often unsuspected. Clinical features of valproate-induced parkinsonism (VPA-P) can mimic Parkinson’s disease and may be confusing especially when they occur in older men. A case of a 75-year-old man with ten years history of epilepsy treated with Depakine Chrono who developed parkinsonism in the last two years is described. Antiparkinsonian treatment with Madopar HBS even in high dosage was ineffective. The characteristics and possible mecha-nisms of VPA-P are described. Despite the good safety of VPA therapy for several years, clinicians should have a high suspicion for VPA-P especially in old patients and this possibility should be considered in the differential diagnosis. | en_US |
| dc.identifier.citation | Maximov, K. and G. Maximov. Valproate-induced parkinsonism in epilepsy patient – a case report - Acta Medica Bulgarica, 35, 2008, № 1, 38-42. | en_US |
| dc.identifier.issn | 0324-1750 | |
| dc.identifier.uri | http://hdl.handle.net/10861/148 | |
| dc.language.iso | en | en_US |
| dc.publisher | Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia | en_US |
| dc.subject | valproate, epilepsy, parkinsonism. | en_US |
| dc.title | Valproate-induced parkinsonism in epilepsy patient – a case report | en_US |
| dc.type | Article | en_US |