Association of 13q14 deletion with clinico-laboratory parameters in B-cell chronic lymphocytic leukemia (B-CLL)
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Дата
2012-06
Автори
Hadzhiev, E.
Alexandrova, K.
Velizarova, M.
Dimova, I.
Toncheva, D.
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Издател
Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia
Резюме
A deletion of chromosome band 13q14 (13q-) detected by fl uorescence
in situ hybridization (FISH) analysis is the single most common cytogenetic
abnormality in patients with chronic lymphocytic leukemia (CLL). In our study we
disccused the incidence of molecular-cytogenetic deletion of 13q14 marker in BCLL
in order to determine the association of this aberration with clinical manifestation,
laboratory parameters and poor disease prognosis. Patients with 13q14 aberrations
were significantly older. They had ZAP (+) status, rapid disease progression
and therapy dependency. A determination of 13q14 genetic abnormality should,
therefore, be included in the investigations of the prognostic factors of B-cell chronic
lymphocytic leukemia.
Описание
Address for correspondence:
Dr. Milena Velizarova
Department of Clinical Laboratory and Clinical Immunology
University Hospital “Alexandrovska”
1 G. Sofi yski str.
1431 Sofi a, Bulgaria
tel.: +359 2 92 30 916
e-mail: mvelizarova@abv.bg
Ключови думи
deletion 13q14 (13q14 deletion), chronic lymphocytic leukemia, Fluorescence in situ hybridization, ZAP70.
Цитирания
E. Hadzhiev, K. Alexandrova, M. Velizarova, I. Dimova and D. Toncheva. Association of 13q14 deletion with clinico-laboratory parameters in B-cell chronic lymphocytic leukemia (B-CLL) - Acta medica bulgarica , 39, 2012, No 2, 73-81.