HPV-associated Buschke-Löwenstein tumours in a patient with disseminated anogenital form of condylomata acuminata – a dermatosurgical problem
thumbnail.default.placeholder
Дата
2012-06
Автори
Tchernev, G.
Ananiev, J.
Gulubova, M.
Bakardzhiev, I.
Pehlivanov, G.
Gonevski, M.
Zisova, L.
Cardoso, J. C.
Заглавие на списанието
ISSN на списанието
Заглавие на тома
Издател
Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia
Резюме
Buschke-Löwenstein tumours are a relatively rare clinicopathological
entity. However, due to their malignant potential and frequent association with
some types of Human Papillomaviruses (HPV), their diagnosis should be promptly
confi rmed and appropriate management should be planned (according to the condition).
In this article we present a middle-aged patient with long-standing tumoural
lesions located in the anogenital area, which were confi rmed clinically and histopathologically
as well-differentiated squamous cell carcinomas of Buschke-Löwenstein
type, in combination with disseminated anogenital condylomata acuminata.
Histologically, large tumour nests of well-differentiated squamous cell carcinoma
were observed, as well as a marked mononuclear cell infi ltrate and conspicuous
koilocytosis. Immunohistochemistry for Ki-67 revealed a relatively high proliferative
index, and was strongly positive for HPV with a pan-HPV antibody (AK), confi rming
the presence of the virus in the tissue. Surgical removal of the various tumoural
masses was performed by electrodesiccation, combined with shave-curettage under
general anesthesia. Due to the excessive bleeding there was no possibility for
complete removal of the perianal tumour formations and the therapeutic strategy
was revised. Systemic therapy with interferon was planned with the purpose of
reducing the tumour mass before further surgery.
Описание
Address for correspondence:
Assoc. Prof. Georgi Tchernev, MD, PhD;
University "St. Kliment Ohridski"
Polyclinic of Dermatology and Venerology;
Univeristy Hospital Lozenetz,
Medical Faculty;
1 Koziak str.;
1407 Sofi a, Bulgaria
Ключови думи
Buschke-Löwenstein tumour, HPV association, Ki-67, verrucous carcinoma
Цитирания
G. Tchernev, J. Ananiev, M. Gulubova, I. Bakardzhiev, G. Pehlivanov, M. Gonevski, L. Zisova and J. C. Cardoso. HPV-associated Buschke-Löwenstein tumours in a patient with disseminated anogenital form of condylomata acuminata – a dermatosurgical problem - Acta medica bulgarica , 39, 2012, No 2,37-42