HPV-associated Buschke-Löwenstein tumours in a patient with disseminated anogenital form of condylomata acuminata – a dermatosurgical problem
| dc.contributor.author | Tchernev, G. | |
| dc.contributor.author | Ananiev, J. | |
| dc.contributor.author | Gulubova, M. | |
| dc.contributor.author | Bakardzhiev, I. | |
| dc.contributor.author | Pehlivanov, G. | |
| dc.contributor.author | Gonevski, M. | |
| dc.contributor.author | Zisova, L. | |
| dc.contributor.author | Cardoso, J. C. | |
| dc.date.accessioned | 2014-07-10T13:47:07Z | |
| dc.date.available | 2014-07-10T13:47:07Z | |
| dc.date.issued | 2012-06 | |
| dc.description | Address for correspondence: Assoc. Prof. Georgi Tchernev, MD, PhD; University "St. Kliment Ohridski" Polyclinic of Dermatology and Venerology; Univeristy Hospital Lozenetz, Medical Faculty; 1 Koziak str.; 1407 Sofi a, Bulgaria | en_US |
| dc.description.abstract | Buschke-Löwenstein tumours are a relatively rare clinicopathological entity. However, due to their malignant potential and frequent association with some types of Human Papillomaviruses (HPV), their diagnosis should be promptly confi rmed and appropriate management should be planned (according to the condition). In this article we present a middle-aged patient with long-standing tumoural lesions located in the anogenital area, which were confi rmed clinically and histopathologically as well-differentiated squamous cell carcinomas of Buschke-Löwenstein type, in combination with disseminated anogenital condylomata acuminata. Histologically, large tumour nests of well-differentiated squamous cell carcinoma were observed, as well as a marked mononuclear cell infi ltrate and conspicuous koilocytosis. Immunohistochemistry for Ki-67 revealed a relatively high proliferative index, and was strongly positive for HPV with a pan-HPV antibody (AK), confi rming the presence of the virus in the tissue. Surgical removal of the various tumoural masses was performed by electrodesiccation, combined with shave-curettage under general anesthesia. Due to the excessive bleeding there was no possibility for complete removal of the perianal tumour formations and the therapeutic strategy was revised. Systemic therapy with interferon was planned with the purpose of reducing the tumour mass before further surgery. | en_US |
| dc.identifier.citation | G. Tchernev, J. Ananiev, M. Gulubova, I. Bakardzhiev, G. Pehlivanov, M. Gonevski, L. Zisova and J. C. Cardoso. HPV-associated Buschke-Löwenstein tumours in a patient with disseminated anogenital form of condylomata acuminata – a dermatosurgical problem - Acta medica bulgarica , 39, 2012, No 2,37-42 | en_US |
| dc.identifier.issn | 0324-1750 | |
| dc.identifier.uri | http://hdl.handle.net/10861/551 | |
| dc.language.iso | en | en_US |
| dc.publisher | Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia | en_US |
| dc.subject | Buschke-Löwenstein tumour, HPV association, Ki-67, verrucous carcinoma | en_US |
| dc.title | HPV-associated Buschke-Löwenstein tumours in a patient with disseminated anogenital form of condylomata acuminata – a dermatosurgical problem | en_US |
| dc.type | Article | en_US |