Acute exogenic intoxications and level of the antioxidant selenium
| dc.contributor.author | Tufkova, S. | |
| dc.contributor.author | Karaslavova, E. | |
| dc.date.accessioned | 2012-05-07T12:55:26Z | |
| dc.date.available | 2012-05-07T12:55:26Z | |
| dc.date.issued | 2008-06 | |
| dc.description | Address for correspondence: Dr. Stoilka Tufkova, Clinic of toxicology University Multiprofile Hospital “St. Georgi” – Plovdiv 032/ 602-406 0889/302-953 e-mail: tuffi_med@yahoo.com | en_US |
| dc.description.abstract | The human organism possesses a well built antioxidant defence system having as a purpose neutralizing the free radical processes. The antioxidant defence of the human organism can be divided in to three functional levels. Great importance is given to the second level represented by enzyme and non-enzyme components which defuse the already formed free radicals. Here a main representative is the microelement selenium. Aim of the study was tracing the level of selenium – a main element of the secondary antioxidant defence system of the human body in acute exogenic intoxications with cerebrotoxic medicaments, alcohol and heroin. The study is prospective and longitudinal comprising 118 patients with average and heavy degree of acute poisoning with cerebrotoxic medicaments (n=45), alcohol (n=40), heroin (n=33) and control (n=35). The clinical laboratory tests are made under definite standards of the clinical laboratory. Following statistical analyses are used: variational analysis/u-criterion for normal distribution, t-test of Student, dispersive analysis under the method of ANOVA test and non-parametric analysis. Our results show a statistically significant decrease of serum concentration of selenium in acute exogenic intoxications with cerebrotoxic medicaments, alcohol heroin – Р<0,001, without it correlating with the weight of the acute intoxication – Р>0,05. As a reliable marker for a complex estimate of the antioxidant system of humans is the tracing the serum level of selenium and its careful interpretation. | en_US |
| dc.identifier.citation | Tufkova, S. and E. Karaslavova. Acute exogenic intoxications and level of the antioxidant selenium - Acta Medica Bulgarica, 35, 2008, № 1, 25-31. | en_US |
| dc.identifier.issn | 0324-1750 | |
| dc.identifier.uri | http://hdl.handle.net/10861/146 | |
| dc.language.iso | en | en_US |
| dc.publisher | Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia | en_US |
| dc.subject | selenium, enzyme and non-enzyme antioxidants, acute intoxications | en_US |
| dc.title | Acute exogenic intoxications and level of the antioxidant selenium | en_US |
| dc.type | Article | en_US |