Evaluation of molecular-cytogenetic aberrations and overall survival in myeloid antigen positive adult acute lymphoblastic leukemia.
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Дата
2012-04
Автори
Velizarova, M.
Popova, D.
Hadjiev, E.
Dimitrova, N.
Dimova, I.
Toncheva, D.
Tsachev, K.
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Издател
Централна медицинска библиотека, МУ София / Central Medical Library - MU Sofia
Резюме
Leukemic cells from a signifi cant number of adults with acute lymphoblastic leukemia (ALL) show aberrant co-expression of myeloid-associated markers. We studied the incidence and relations of myeloid-antigen (MyAg)
expression to molecular-cytogenetic features of ALL and to outcome. Leukemic blasts from 33 newly diagnosed adults with untreated ALL were examined for myeloid surface antigen expression. The simultaneous expression of lymphoidassociated antigens and myeloid-associated antigen (CD33, CD13, CD15) on
leukemic cells was detected by a standard two-color direct immunofl uorescent
assay. As a result, MyAg(+) ALL was established in 45% of the B-cell lineage.
Immunologic subtyping of B-ALLs revealed an association between common B phenotype and coexpression of myeloid antigens – 53% of MyAg(+)ALL (P < 0.05). Various cytogenetic abnormalities, associated with MyAg(+) ALLs, were detected, including t(9;22), 11q23 abnormalities, del 4p, and del 12p. No differences in complete remission rate (p = 0.51) and overall survival (p = 0.75) were
observed between MyAg(+) and MyAg(-) patients. In conclusion, a high incidence
of poor prognostic chromosomal aberrations was recorded in MyAg (+) cases, but
the aberrant myeloid antigen expression was not shown to have an impact on the outcome of B-ALL.
Описание
Address for correspondence:
Dr Milena Velizarova, PhD
Department of Clinical Laboratory and Clinical Immunology; University Alexander’s Hospital;
1 G. Sofiiski str.;
1431 Sofia, Bulgaria;
tel. +359 2 92 30 916 ;
e-mail: mvelizarova@abv.bg
Ключови думи
cytogenetic aberrations, myeloid antigens, adult ALL, survival
Цитирания
M. Velizarova, D. Popova, E. Hadjiev, N. Dimitrova, I. Dimova, D. Toncheva and K. Tzatchev. Evaluation of molecular-cytogenetic aberrations and overall survival in myeloid antigen positive adult acute lymphoblastic leukemia - Acta medica bulgarica , 39, 2012, No 1, 40-46.