Three cases of acute myeloid leukemia and deletion of the long arm of chromosome 9.
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Дата
2013-06
Автори
Mitev, L.
Velizarova, M.
Uzunova, V.
Stanchev, R.
Gigоv, I.
Rainov, J.
Vladimirova, R.
Tsachev, K.
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Издател
Централна медицинска библиотека - МУ София / Central medical Library - MU Sofia
Резюме
Deletion of the long arm of chromosome 9 (del 9q) is a recurrent
cytogenetic abnormality in acute myeloid leukemia (AML) and myelodysplastic syndrome
(MDS). We describe the first three de novo AML cases with del(9q) in our
country, found as the sole karyotypic anomaly. Karyotyping indicated two areas
of deletion – in the regions 9q21-22 and 9q13-34. There was found the association
of del(9q) with characteristic phenotypic abnormalities: blasts with or without
cytoplasmic granulations, dysplastic changes in granulocyte lineage, giant myeloperoxidase
positive cytoplasmic granulations (pseudo-Chediak-Higashi type) and
CD7(+) and CD34(+)/CD34(-) antigen expressions. In one of the patients there was
also an association with dysplastic changes in erythroid, granulocytic and megakaryocytic
lineages. It is likely that del(9q) is a clonal event in the pre-leukemic
stage of the disease, probably in unrecognized MDS. Deletion of tumor-suppressor genes in 9q chromosome regions may relate with leukemogenesis in AML.
Описание
Address for correspondence:
Assoc. Prof. Dr. L. Mitev;
Military Medical Academy;
Dept. Clinical Laboratory and Immunology;
3 G. Sofiyski St.;
1431 Sofia;
e-mail: cytogen.vma@abv.bg
Ключови думи
acute myeloid leukemia, 9q abnormalities, cytogenetics of acute leukemia
Цитирания
L. Mitev, M. Velizarova, V. Uzunova, R. Stanchev, I. Gigоv, J. Rainov, R. Vladimirova and K. Tsachev. Three cases of acute myeloid leukemia and deletion of the long arm of chromosome 9 - Acta medica bulgarica , 40, 2013, No 1, 10-17.