Three cases of acute myeloid leukemia and deletion of the long arm of chromosome 9.
| dc.contributor.author | Mitev, L. | |
| dc.contributor.author | Velizarova, M. | |
| dc.contributor.author | Uzunova, V. | |
| dc.contributor.author | Stanchev, R. | |
| dc.contributor.author | Gigоv, I. | |
| dc.contributor.author | Rainov, J. | |
| dc.contributor.author | Vladimirova, R. | |
| dc.contributor.author | Tsachev, K. | |
| dc.date.accessioned | 2015-07-08T12:33:04Z | |
| dc.date.available | 2015-07-08T12:33:04Z | |
| dc.date.issued | 2013-06 | |
| dc.description | Address for correspondence: Assoc. Prof. Dr. L. Mitev; Military Medical Academy; Dept. Clinical Laboratory and Immunology; 3 G. Sofiyski St.; 1431 Sofia; e-mail: cytogen.vma@abv.bg | en_US |
| dc.description.abstract | Deletion of the long arm of chromosome 9 (del 9q) is a recurrent cytogenetic abnormality in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We describe the first three de novo AML cases with del(9q) in our country, found as the sole karyotypic anomaly. Karyotyping indicated two areas of deletion – in the regions 9q21-22 and 9q13-34. There was found the association of del(9q) with characteristic phenotypic abnormalities: blasts with or without cytoplasmic granulations, dysplastic changes in granulocyte lineage, giant myeloperoxidase positive cytoplasmic granulations (pseudo-Chediak-Higashi type) and CD7(+) and CD34(+)/CD34(-) antigen expressions. In one of the patients there was also an association with dysplastic changes in erythroid, granulocytic and megakaryocytic lineages. It is likely that del(9q) is a clonal event in the pre-leukemic stage of the disease, probably in unrecognized MDS. Deletion of tumor-suppressor genes in 9q chromosome regions may relate with leukemogenesis in AML. | en_US |
| dc.identifier.citation | L. Mitev, M. Velizarova, V. Uzunova, R. Stanchev, I. Gigоv, J. Rainov, R. Vladimirova and K. Tsachev. Three cases of acute myeloid leukemia and deletion of the long arm of chromosome 9 - Acta medica bulgarica , 40, 2013, No 1, 10-17. | en_US |
| dc.identifier.issn | 0324-1750 | |
| dc.identifier.uri | http://hdl.handle.net/10861/656 | |
| dc.language.iso | en | en_US |
| dc.publisher | Централна медицинска библиотека - МУ София / Central medical Library - MU Sofia | en_US |
| dc.subject | acute myeloid leukemia, 9q abnormalities, cytogenetics of acute leukemia | en_US |
| dc.title | Three cases of acute myeloid leukemia and deletion of the long arm of chromosome 9. | en_US |
| dc.type | Article | en_US |