Impact of body mass index on insulin sensitivity/resistance in pregnant women with and without gestational diabetes mellitus
| dc.contributor.author | Genova, M. | |
| dc.contributor.author | Todorova-Ananieva, K. | |
| dc.contributor.author | Tzatchev, K. | |
| dc.date.accessioned | 2015-08-07T12:03:47Z | |
| dc.date.available | 2015-08-07T12:03:47Z | |
| dc.date.issued | 2013-09 | |
| dc.description | Address for correspondence: Mariana P. Genova, MD, PhD; Department of Clinical Laboratory and Clinical Immunology; Medical University; University Hospital “Alexandrovska”; 1 G. Sofiiski St.; 1431, Sofia, Bulgaria; e-mail: mariana8sofia@yahoo.com | en_US |
| dc.description.abstract | Summary. The aim of the present study was to evaluate the impact of body mass index (BMI) on homeostasis model assessment (HOMA) and insulin sensitivity, using the quantitative insulin sensitivity check index (QUICKI), and homeostasis model assessment value for insulin sensitivity (HOMA-S) in pregnant women with normal glucose tolerance (NGT) and gestational diabetes mellitus (GDM). A total of 102 pregnant women between 24-28 gestational weeks (53 with GDM and 49 with NGT) were included in the study. Age, body mass index (BMI), week of GDM diagnosis, fasting plasma glucose and insulin concentrations were measured in all women. HOMA indexes (insulin resistance – HOMA-IR and HOMA-B), QUICKI and HOMA-S indexes were c alculated from fasting glucose and insulin concentrations. BMI was significantly higher in GDM patients (32.6 ± 4,39) compared to their NGT (26.83 ± 5.54) weight-matched group (p < 0.011). HOMA-IR in women with GDM was significantly higher than those in women with NGT (p < 0.0001). QUICKI-IS and HOMA-S were significantly lower in GDM group (p = 0.001; p = 0.002, respectively). The correlation between BMI and HOMA-IR were r = 0.594; r = 0.485, p < 0.0001 for GDM and NGT, between BMI and QUICKI (r = -0.603; r = -0.458); between BMI and HOMA-S (r = -0.679; r = -0.467 for GDM and NGT pregnant women). In our study, compared BMI of pregnant with NGT and GDM demonstrated that the OR of developing GDM was 1.099 (95% CI, 1.028-1.176, p = 0.006). According to our results, insulin sensitivities determined by QUICKI and HOMA-S are lower in GDM than NGT group, but GDM pregnant women have statistically higher HOMA-IR. We found higher positive correlation between BMI and HOMA-IR, and markedly negative correlation between BMI, QUICKI-IS and HOMA-S in pregnant women with GDM in comparison to NGT. Moreover, we observed that higher BMI decreasd insulin sensitivity, increased insulin resistance and contributed to development of GDM. | en_US |
| dc.identifier.citation | M. Genova, K. Todorova-Ananieva and K. Tzatchev. Impact of body mass index on insulin sensitivity/resistance in pregnant women with and without gestational diabetes mellitus - Acta medica bulgarica , 40, 2013, No 2,60-67. | en_US |
| dc.identifier.issn | 0324-1750 | |
| dc.identifier.uri | http://hdl.handle.net/10861/716 | |
| dc.language.iso | en | en_US |
| dc.publisher | Централна медицинска библиотека - МУ София / Central Medical Library - MU Sofia | en_US |
| dc.subject | body mass index, gestational diabetes mellitus, homeostasis model assessment, quantitative insulin sensitivity check index | en_US |
| dc.title | Impact of body mass index on insulin sensitivity/resistance in pregnant women with and without gestational diabetes mellitus | en_US |
| dc.type | Article | en_US |